Genetics

Blue-eyed cats with white fur have a reputation for having greater incidence of genetic deafness.
A 2007 study published in the journal Science asserts that all house cats are descended from a group of self-domesticating desert wildcats Felis silvestris lybica circa 10,000 years ago, in the Near East.[4]
The domesticated cat and its closest wild ancestor are both diploid organisms that possess 38 chromosomes,[26] in which over 200 heritable genetic defects have been identified, many homologous to human inborn errors. Specific metabolic defects have been identified underlying many of these feline diseases. There are several genes responsible for the hair color identified. The combination of them gives different phenotypes.
Features like hair length, lack of tail or presence of a very short tail (bobtail cat) are also determined by single alleles and modified by polygenes.
The Cat Genome Project, sponsored by the Laboratory of Genomic Diversity at the U.S. National Cancer Institute Frederick Cancer Research and Development Center in Frederick, Maryland, focuses on the development of the cat as an animal model for human hereditary disease, infectious disease, genome evolution, comparative research initiatives within the family Felidae, and forensic potential.
All felines, including the big cats, have a genetic anomaly that may prevent them from tasting sweetness, which is a likely factor for their indifference to or avoidance of fruits, berries, and other sugary foods.